Obesogens
94Are fat people always at fault for their condition? If you eat right, exercise daily, and lead a balanced lifestyle, will this always be enough to keep you fit and trim? Is the obesity epidemic in the United States today entirely a matter of poor self-control, a combination of gluttony and sloth? Or are there other reasons for obesity besides overeating and underexercising?
Recently, I read an article in Newsweek about obesogens, substances that can disrupt the normal balance in our bodies and incline us toward obesity. What caught my attention was the statement that sometimes weight gain occurs in people who eat no more than others of comparable age and who exercise no less. In a group of babies under the age of six months, one can already detect serious differences in the way that body fat accumulates, even when they have a similar diet and the same exercise regimen.
Obese children are common in the United States
The term "obesogens" was coined by Bruce Blumberg of the University of California, Irvine. It refers to substances in the environment that might disrupt the metabolic process. What subtances are these? And is there any study that definitively links these substances with the obesity epidemic?
That's where the obesogen story strikes many of us as rather weak. "Exposure to environmental chemicals during development may be contributing to the obesity epidemic," Newsweek quotes Retha Newbold of the National Institute of Environmental Health
Sciences (NIEHS) in North Carolina, part of the National Institutes of
Health (NIH), as saying, But is there any evidence?
Newbold gave low doses of estrogen-like compounds to newborn mice. According to the Newsweek article: "In six
months, the mice were 20 percent heavier and had 36 percent more body
fat than unexposed mice." These weight gains occurred without allowing the obese mice access to more food than controls, and the obese mice were not any less active than the controls. They gained weight on the same diet and the same amount of exercise as their fellow mice who were not obese!
Newsweek quotes Newsbold as saying: "What was so odd was that the overweight mice were not eating more or moving less than the normal mice. We measured that very carefully, and there was no statistical difference."
What does this prove?
I got a little excited when I read about Newbold's experiment with the mice. But it wasn't because I was convinced that unnatural substances in our environment are the cause of the obesity epidemic. I think the experimenters are still a long way from proving that. It would take much more to link specific environmental chemicals to the weight gain in the general population -- and even in very young children.
The thing that excited me was the idea that there is more to weight gain than the simple arithmetic process of adding up the calories you eat and subtracting the calories you burn. I've always suspected that there was more to weight gain than budgeting calories.
Different Factors in Weight Gain
Even among newborns of comparable body length, some weigh considerably more than others. It's hard to say what exactly contributes to this discrepancy, because as we all know, unborn babies are not all receiving the same caloric input, and they are not all equally as active. Some kick and squirm a lot in utero, and others are so inactive that they cause concern even before they are born.
After birth, parents are even more aware of the baby's activity level. Some babies, even when lying flat on their back, fidget and squirm a great deal more than others, and it is quite likely that more active babies burn more calories. Noting a tendency toward obesity in those under six months of age does not necessarily correlate with environmental disruptors.
But the experiment with the mice showed something important: there is more to weight gain than the calories we burn and the calories we consume.
The Savings/Spending Metaphor
We can use an economic metaphor to explore the different factors that go into a person's weight gain or loss. Think of calories consumed as the person's income. Think of money spent as calories burned. The traditional take on weight management is that if you want to put on weight, you should increase savings, by reducing spending or increasing income. (That is, exercising less or eating more.) If you want to lose weight, you should save less, by spending more or reducing your income. (That is, exercising more and eating less.)
In this metaphor, body fat is savings. Just as many people think that wealthy people are bad, so there are many among us who pass judgment on the obese for being fat. But we all know, don't we, that there's much more to how much you save than what your income is and how much of it you spend?
Consider Tom and Harry, two co-workers who earn the same salary, live in houses that are equal in valuation and drive exactly the same car. Let's say they also spend the same on groceries and entertainment and the like. In short, their income and their spending are exactly the same. Does this guarantee that their savings will be the same? No, it does not.
What if Tom keeps all his extra money in CDs and high yield money market accounts, and Harry keeps his extra money in the mattress? What if Tom always pays with exact change in the supermarket, while Harry pays with full dollar bills and then tosses the change haphazardly on the counter, or under the bed, or into the sofa? What if Tom uses tax shelters and loopholes to shield his income from marauders and Harry does not? What if Tom pays cash for major purchases and Harry uses credit? At the end of the year, who will have more savings?
Efficiency in managing our resources can be a factor. This is true when it comes to money. It is no less true when it comes to calories. Some people are fat because they overeat. Some people are fat because they don't exercise enough. And some people are fat because their bodies are unusually efficient in storing fat!
If the body has more fat cells, it can store fat more efficiently
In 2006, according to the Newsweek article on obesogens, Bruce Blumberg fed pregnant mice tributyltin, a disinfectant and fungicide which enters the human food chain in seafood and drinking water. "The offspring were born with more fat already stored, more fat cells, and became 5 to 20 percent fatter by adulthood," Blumberg told Newsweek.
How did this happen? Apparently, the tributylin activated a receptor site called "PPAR gamma" which switches embryonic cells from being fiborblasts to becoming fat cells. When a baby mouse is born with more fat cells, apparently it is able to store more fat after consuming the same number of calories than another baby mouse that was born with fewer fat cells. Because there is better storage for fat, the accumulation of fat proceeds more efficiently, and fewer calories are frittered away. If this works for baby mice, it might very well be true of human babies as well.
Diversity and Tolerance
Are there human children who are born with more fat cells? And if so, is this due to obesogens in the environment? It may be too early to decide. But one thing seems to be proven already: efficiency in processing calories is a factor in weight gain.
It's not necessarily the case that all congenital tendencies toward obesity involve a higher number of fat cells in the embryo. Efficiency in processing calories may also involve the basic metabolic rate of each individual. Some people burn more calories even while at rest than do others. Inefficiency in regulating body temperature may be a factor for some people. It's like two households that keep their thermostat set to the same temperature, but one has a house with faulty insulation. How much they are able to save can be affected by an energy leak.
In an affluent society such as ours, bodies that are too efficient in processing caloric resources may be less desirable. It's easy to put on weight, so the laws of supply and demand make a skinny body more sought after. In the U.S. today, healthier and wealthier people have bodies that don't process energy so efficiently as to put on much fat. However, the tables could easily be reversed, and an economic collapse may lead to a situation where greater efficiency is more desirable again, as it was with our ancestors in past generations. Under those conditions, fat people might suddenly find themselves healthier, wealthier and more popular.
For those people who put on more weight than others for the same number of calories consumed, without exercising less, one way to avoid obesity might be to decrease the efficiency with which calories are processed. One way to do this is to choose a diet low in carbs. Since carbs are easier for the body to process into energy, consuming calories that are not in the form of carbs may lead to storage of less fat. That is, if you want to store less fat.
But let's face it, in a famine, those with more body fat are more likely to survive, and those whose efficiency in fat storage is high will have an advantage. So before we decide that efficiency in saving calories is always a bad thing, we should consider all possible environments.
In an inflationary economy, people burdened with wealth suffer, and it is wise not to accumulate savings. In a deflationary economy, those with savings may prosper. Before you condemn someone who has savings for greed or avarice, consider that he may not have had more income than you or spent any less. He may simply be more efficient at processing the income he has.
By the same token, when you meet someone with more body fat than you have, don't assume he got that way by gluttony or sloth. He may simply be more efficient at processing calories than you are. In a famine, that skill will come in handy!
It takes a diverse population to ensure human survival. You never know when the environment may favor a different body type than the one that is currently popular. Before we pass judgment on others for the way they are, maybe it would be good to consider all the possible benefits of each person's assets. There is more than one way to be!
(c) 2009 Aya Katz
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Hi Aya,
I am intrigued by your hub in which you disprove the law of conservation of energy.
(But why do you think the only way of getting rid of calories is to burn them?)
Its the little things... If two people are identical in every way but one goes to Starbucks every day and buys a large mochachino and the other doesn't, the one who doesn't will have $1000 surplus in a year. you might think 1 mochachino is no biggie but in a year it adds.
There probably isnt a whole lot we can do about chemical crap that is already in our systems so we have to think of ways to spend all that loose change so to speak, and that boils down to fidgeting more and eating less crap.
I think what we eat has a profound effect on our ability at exercise. When you pump on refined starch and sugar it makes your insulin go wild and your body goes into WTF mode and maybe you don't feel quite so optimal so you take the elevator instead of the stairs which makes you fat and less inclined to exercise the next time....
I liked your analogy with Tom and Harry as it makes a lot of sense. Much of the problem of obesity stems from inactivity and laziness as many people choose to eat fast foods as it is cheap and convenient. It's tough to avoid passing by them to and from work. I've been that route before (ha ha) and so know such pitfalls after gaining nearly 40 pounds because I was too spent to cook for myself. I actually went on a protein diet which works wonders if you stick with it, but you have to be extremely disciplined in doing so.
Thanks again Aya for a wonderful and useful hub!
Lots of food for thought here on this hub that'll have me thinking on it for days. To me I see the fact that virtually everything most people eat having so much unnatural stuff added to it as another key factor in the many causes of obosegens?
Great hub Aya - gives one a lot to think about! It scary, isn't it, when you think of how many substances can contribute to gaining weight. Growth hormones, too can be bad news - I'm not sure if this is true, but they say no matter how long you cook meat, the hormones can still be active.
Very interesting hub. We have been messing about with our food way too much. You are of course right that there is more than one way to be but obesity levels are now getting ridiculous in many western countries - certainly to levels that have never been seen before in history. I wrote a hub recently on the 'toxic environment' that leads people to become obese - the argument is that there is too much high calorie, easy food where ever we go and that our will power is only good up to a point. At any rate it is a complex issue that is for sure.
Very interesting, and I'm inclined to agree with you about differences in weight. When I see a morbidly obese person, I think "metabolic/hormonal disorder," not "laziness," since many of them get more exercise (some having physical labor jobs) than sedentary thin people. I think a mentality that assume obesity is caused by a character defect impedes our ability to understand and solve the disorders that cause it.
My partner, who is "naturally thin," is a good example. When he wants to gain weight, he starts to eat more, but his body does something: he literally emanates heat constantly. His body is trying hard to get rid of his extra consumed calories. Despite his best efforts, he usually returns to the same naturally thin build.
On the other hand, a friend of mine is predisposed to being overweight, and whenever she controls her diet (eating a moderate, healthy diet), her body becomes literally cold - it is trying to conserve heat at all costs. Her hands are usually ice cold unless she is overeating and gaining weight.
Everyone has a different metabolism rate so it is true that some people have to work harder to burn the same amount of calories. That being said, even if you eat the right foods, you can still over eat. Very interesting hub.
Plenty of good foods out there than one should consider on including in their diet. Actually learned a few new things on this hub, thanks for providing it: :)
This was a great hub. Weight gain has definately been on my mind in the past few years. I, too, am one of those eat-right types that still gains weight. There are other mitigating factors, as I am finding out. Hormones and aging, developing fat to store toxins, and stress - just to name a few. It is certainly disheartening when your doctor just looks at you and shrugs when you are trying to find answers. Ahh well, at least I have great blood pressure! :D
Thank you for this informative hub. Most people who are not obese have no idea what motivates the obese person. The issue that caused the problem may have no relevance to failure to lose weight. There are several major problems for the obese person to work on.
1. Fast food becomes a habit. Changing from grabbing fast food to eating and cooking at home is hard. But...it makes a difference in weight control.
2. Exercise. You will never entice people who do NOT like exercise to become an exercise lover. Is very unlikely to happen.
3. In spite of popular opinion, as a weight challenged person, I CANNOT eat 4 to 6 meals per day! I am not a grazer and this leads to weight gain! I know all about portion control and this is an ongoing battle.
4. When you reach a certain age your metabolism changes and the situation just gets worse.
5.I know many people think it is just gluttony and laziness, but I can state for a fact that NO one ever decided to be fat. I never dreamed when I was younger that I would find myself in this condition. I have been visualizing the person I used to be and wondering what changes I could make to become that person again.
Just wanted to offer some insight.
Great hub.
Very nice and informative hub. I think there are so many different reasons for people being obese, psychological, physiological, etc...
I realized as a teenager when my friend and I hung out together all day and ate all our meals together that she remained thin and I remained overweight (by like 20 pounds). I couldn't understand why she didn't gain or I didn't lose or what?? When I mentioned this one day she said "I have nervous energy" which kept her moving alot and probably meant she had a sped up metabolism. I on the other hand ended up at an endocrinologist when I was around 30 and he told me I had a "sluggish metabolism" and should exercise everyday and consume only 1200 calories per day....hmmm, today they would tell you that is unhealthy.
I keep a food diary and go to the gym 3-4 times a week now (I am 49) needless to say my metabolism is no doubt more sluggish. What I have found is even when I am eating religiously healthy and working out, I only lose weight if I take in less than 1200 calories a day. No matter how healthy my food choices are. My husband says I have the perfect metabolism for survival back in the days of the cavemen. My friend who remained thin he said, would have never survived. Unfortunately, I am not sure I want to live on nuts and berries and some occasional wild bore....
No comment. But every little helpsW
www.aloeverahealth4u.com
I believe many obese people are not at fault even if they are so because they eat too much. They are products of the marketing machine that hires psychologists to figure out how to convince them to eat their salt, sugar, and fat.
There are also those who have pituitary problems or metabolism hindrances. This (obesity) is largely the fault of the fast food giants and the cartoon advertisers who prey upon our children.
Very informative hub. Kinda casts some doubt to the burn more calories than you take in to create a deficit and lose weight. appears weight loss success and obesity may involve much more than previously thought.
Robert Ballard
Great hub! I have a pal who tries to gain weight and can't. When we worked together, he ate all day - chocolates, pastries, soft drinks - while I ate salads. When we left work, I'd go straight to the gym and he's go home for a nap. He remains thin, and I'm fat. Not fair!
I tend to agree completely with the comment made by Scott.Life. I have had a weight problem, off and on, most of my life. When I learned simply how to recognize quality food my being overweight was no longer a problem. I changed the way I eat. I don't exercise more than 20 minutes a day. And, the excess weight is gone.
Great Hub! I have to agree with Scott.Life. He is right on.
Another thing that has contributed largely to the obesity rate that no-one has mentioned is High-Fructose Corn Syrup. You may or may not know this, but the top 3 ingredients in a product represent the majority of what is in that particular product sold in the stores. There is a direct correlation with the implementation of this additive into food products in the 1980's and the rise in obesity. If you look at the labels on most "FAT FREE" products, you'll see High-Fructose Corn Syrup in the top 3. This is pure sugar and is deceiving the consumer that they are consuming a healthier alternative. Same goes with the steroids and antibiotics that are injected into the foods we eat.
Bottom line, it's important that the consumer is educated not just on what type of foods to eat and avoid, but how to read nutritional labels.
You must eat as much as you can and put the weight on! One day all the food will be gone and you will be sorry you didn't eat it!
This is a very informative piece! And it presents an entirely new (at least to me) variable to this health issue. Very thorough. I enjoyed your historical perspective, and *adore* your conclusion. :)
I have to agree with Stanwshura, right on.
intresting debate, thanks
Like the hub, and it was a lot I didn't know about or consider. But I really think it has a lot to do with metabolism!!!!!
The Law of Conservation of energy states: "Energy cannot be created or destroyed"
This means that you can't put on weight unless you feed your body energy in the form of food. Some bodies use this energy differently but the bottom line is that if your output is less than your input the energy is conserved in the form of fat.
For losing weight, the choice will always be: Eat less, work more, or both.
"Work" here refers to all metabolic activity, including that done to maintain life when we are at rest.
People looking for justification of their weight used to blame the "fat gene" , now they may turn their focus on "obesogens". This is the easy way out, much like the takeaway food they live off is.
The day someone gains weight without eating calorie rich food is the day we plug them in as a battery and solve the energy crisis
Very interesting. I'm afraid I cannot hide behind this as I know I tend to eat a little too much at times. The old emotional eating!!
While there are conditions which create weight gain they cannot be the cause behind the epidemic weight gain in developed coutries all around the world.
Our food is getting more and more processed and we are getting more sedentary these are what need changed.
I totally agree with Scott.Life. What you eat are very important to weight gain/loss.
graet hubs, thanks for posting
In my opinion, its calories in, calories out. There is nothing magic about this formula. Some people may store fat more efficiently than others, and thus gain more fat by overeating more quickly, BUT, If I eat 2000cals and burn 2000 cals every day, I don't see how I can gain any weight.
Very informative article. This issue needs to be addressed.
Great hub! I hope more research is done on this as I've struggled with weight for all of my adult life. I take full responsibilty for my weight, but it's always interesting to see what research is being done in regards to obesity.
I also think, It also depends on our body, As few guys eat much but they never get fat and some eat less but can't control the weight. jog regularly , i think thats best way to loss fat. Betwene nice Lens.
This is interesting information that I had never read before. Thanks.
thanks very nice
Obesogens, definately something worth researching, and some interesting comments. I think I will have to come back and allow more time to understand it. At one time, many years ago I could easily lose 5 lbs in two days, now I cant in two months!
Okay I am so sick of people allowing others to use poor excuses for an unhealthy lifestyle. This country always has an excuse for everything!
The people who honestly are forced to gain weight are people with thyroid problems (which like a very small percentage)
And yes, I am aware that there can be other attributing factors such as genetics, metabolism rate, emotional trauma, hormonal changes etc but those are also just obstacles that can be overcome without medication.
There's nothing wrong with gaining weight or being heavier, or liking yourself for being curvier; just don't create bad excuses for it!
staying natural in most areas keeps the body in better shape...just remember when you do exercise your body needs fuel, don't cut back on those extra (healthy calories) thanks for info :)
I have been saying that foodborne and environmental chemicals disrupt the body's fat metabolism mechanism for around 15 years, but until recently have not been able to provide any evidence. Call them obesogens if you must, but certain petroleum-based chemicals (including xenoestrogens) are well documented as having endocrine disrupting effects, including gender-bending, infertility, fat gain and resistance to fat loss.
Think of it this way...
In a perfect endocrine environment, the calorie theory works. Calories in minus calories out leaves a person with a surplus or deficit weight. This agrees with the 1st law of thermodynamics and makes sense. However, if the chemical mechanisms which mobilise fat from the fat cells is not functioning correctly, then all the exercise in the world will not cause fat loss. It has been widely documented that somatotropin (otherwise known as human growth hormone) is abnormally low in obese/overweight people. GH is the hormone which triggers a receptor on each fat cell which in turn releases fat (simplified explanation). If GH is not being secreted by the [pituitary gland at sufficient levels to perform this task, then fat cannot be shed optimally, and so weight loss becomes problematic.
The secondary problem is hyperinsulinemia (over-reactive insulin). The more obese a person is, the worse the insulin reaction is to carbohydrates. It's like an allergy to carbs/sugars, which does not exist in people whose endocrine system is functioning normally. I can eat loads of carbs and sugars (read lots of calories) and my weight hasn't budged for 20 years. If a slightly overweight person ate the same as me, they would store more fat and to make matters worse, they would find themselves strongly attracted to carbohydrates (almost addicted).
This all indicates that obesity is a disease, an endocrine imbalance being caused by non-food and non-lifestyle factors over which we may have limited influence in our personal lives. What do you think happens to all the chemicals our bodies are bombarded with? They cannot be metabolised by our body, and are treated as invaders (toxins), stored in the body's trashcans (the fat cells), meant for collection by GH each night (the garbage truck), but when the garbage truck arrives, the trashcan is locked and cannot be emptied. So goes the cycle, on and on.
Unless a person is at their body's ideal natural weight, this malfunction cannot be controlled by exercise and diet. That said, careful control of how we eat can return the body to 'normality', except that the underlying condition is still there and the predisposition to fat storage and resistance to fat mobilisation never goes away.
...at least until scientists figure out a way to permanently reset the endocrine system (highly unlikely).
I buy lots of fresh fruits and vegetables, and avoid canned and processed food. We eat a simple piece of lean meat a couple times a week, fish and shrimp, Lean Pockets, and Healthy Choice TV dinners. Oh, I do use canned beans a couple times a week. No sugared or artificial sugared drinks, only a little salt or low sodium, no high fructose corn syrup, no fruit juices, no syrups, only honey(a little), no bread, no bananas (as I find it is hard to only eat one). We do eat pancakes at times with natural fruit jelly.
Anyway, the point to me is to quit arguing about diet and losing weight and to eat healthy.
I really liked this article, and not just because Im overweight, lol. I'm not by far the worst. I'm just glad that someone else has considered the thought that there may be more to this epidemic than Just genes & calories & exercise. My problem however, lol honestly, is probably genes and the fast food I spent the first 17 years of my life eating. But everyone in my family is aleast a few lbs over weight, so genes is I think the biggest problem. Because all though I've turned into a real health nut, I havent noticed any significant weight loss. However, even for those who aren't a victim to bad genes or anything of the like, there are still some not completely to blame. People say that Chicken is healthier than Pork, Beef, etc. However... all forms of meat these days (excluding organic and all natural ofcourse) are subject to hormones that... increase...the.. size... of the animal, and speed.. up.. the.. growth.. process. We absorb these things when we consume them. Unfortunately, most people cannot afford organic or even all natural all the time so who should we complain to for That?
For some of us, it's not the little things that add up, and it's not the types of food we eat. I should know. I'm living proof of that.
I have struggled with my weight my entire life. There is not a single day I can remember where my weight was not a struggle. From earliest childhood, and especially since puberty, I always have carried around an extra 20-25 lbs.
For the past 10 years, I have stuck to a low-carb, low-sugar, high fiber, vegetarian diet.
More recently, I have also been cutting out dairy products. I do not use artificial sweeteners, and I never touch soda, diet or otherwise. I only drink water, tea, coffee, and soy or almond milk on a regular basis, as fruit juice, even when it is 'no sugar added', is very high in sugar.
I SCRUTINIZE every label. I never touch any food that has more than 10g net carbs per serving, or 5g of sugar. As I also no longer eat dairy, the only fats I get are those from plant sources (nuts, olive oil, avocados).
Although I am not currently 'working out', I don't own a car and get around mostly by foot, so I do get a fair amount of exercise in my daily life. In addition, I have worked out in the past, both with a personal trainer, and in classes where I would hear about how everyone else in the class was losing weight, while I stayed the same...the same...the same...the same...
Yes, I have had my thyroid tested, and it's supposedly normal. (Though I've only had the TSH, not the more sensitive T3 or T4 that normal doctors don't give).
Ironically, when I've had bloodwork done, doctors are always surprised to learn that not only is my cholesterol and blood pressure extremely low, but I also have exceptionally low blood sugar and toxin levels, as a result of my strict diet.
YET, this is not reflected in my weight.
I really wonder why you're so reticent to believe that obesogens are real, because the case studies I've read have been highly convincing.
I can't go by percentages, because those percentages are based on the FDA 'Food Pyramid' recommendations, which are a far, far cry from my general diet.
However, I will say that I mostly eat unprocessed foods in their natural state anyway, and those don't have labels.
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Scott.Life 2 years ago
I think it has become an issue of not so much calorie intake but what kind of calories. Two people can indeed consume the same exact number of calories and exercise, but if one consistently eats a diet filled with processed foods and sugars they will gain weight, as the body adjusts to meet the routines. I think and believe given what i have observed in my own weight loss clients that the quality and ingredients of food are the greatest contributors to fat loss or gain. My clients have seen the biggest weight loss goals by changing what they eat, many actually consume more calories now then when they started. Our food is the problem. Partnered with a more sedentary lifestyle filled with modern conveniences to encourage laziness it's no wonder obesity is on the rise.